Friday, September 21, 2007

Just fer Today,TGIF~~~~






This WAR on HIV must be won by education & awareness! So ya today was friday & it was 22c & partly cloudy.I went & signed in again & as i picked up my carries yesterday,am already to go,only i have no place to go.Home ,thats iy.I wish i could find a woman to enter my life .It would make a big difference i think.Haveing only jerry comin over just doesn't cut it.I got a letter from franco & of course he asks for cash,nice guy that i am i helped out as i know how it is to be broke in there,=sucks large!So i mailed him 25.He could use it i'm sure.I talked with sylvie today about makin out a calender ahead of time for events for the group.Crafts & movies will be there fer sure.Not sure what else yet,but i'm sure we could arrange some tours at local places.& maybe even pay $$ & check out horse riding or go-cart riding among other fun group things=bolr\wling as well.Well thats all from mefer now,GODBLESS & have a great fall all~~!

Tuesday, September 11, 2007

Pill boxes Should Be WIDELY USED,Study Says






This WAR on HIV must be won by education & awareness!
Pillboxes should be standard issue for HIV patients, study concludes printer friendly version send to friend glossary comment
Keith Alcorn, Monday, September 10, 2007
Using a pill box to organise daily doses of antiretrovirals significantly improves adherence and is associated with a greater reduction in viral load and a higher probability of having an undetectable viral load, researchers from the University of California San Francisco report in the October 1st edition of Clinical Infectious Diseases.

In an accompanying editorial Canadian adherence experts say that pillboxes should be widely used, but warn that in patients with very poor adherence, they may not provide enough reinforcement of adherence to show any benefit.

Pillbox organisers, which may contain separate compartments for each dose or each day of the week, are widely available in North America and Europe, and are distributed free of charge by some pharmaceutical companies.

Pillboxes may help patients to spot when they have missed doses, and are also easily portable, releasing people from the need to carry multiple bottles of medicines when they are away from home.

The San Francisco study looked at the effect of pillbox use on adherence in a cohort of 245 HIV-positive patients largely recruited between 1996 and 2000 from homeless shelters and services targeting the downtown `street` population of the city.

The study was a non-randomised analysis of adherence levels, during which participants underwent unannounced pill counts every three to six weeks at their residence over a twelve-month period. Unannounced pill counts reduced the risk that participants with poor adherence would get rid of pills in order to disguise poor adherence, the authors note.

Adherence in patients not using a pillbox was assessed using an electronic medication monitor on the pill bottle of the most frequently dosed drug in their antiretroviral combination.

The analysis controlled for a wide range of confounding factors, including substance abuse, homelessness, prior adherence, viral load, CD4 count, sex, age, ethnicity and sexual orientation.

During the follow-up period 163 participants used a pillbox for at least one month, and pillboxes were used for 43% of the total person-months of observation accumulated during the study.

Sixty-three per cent were taking protease inhibitor-based combinations, often with high pill numbers, and 42% had a previous history of single or dual nucleoside analogue exposure prior to starting triple combination therapy, indicating a high vulnerability to viral rebound and the development of drug resistance.

The mean adherence rate was 73% during the study. Pillbox use was associated with an improvement in adherence of 4.1% - 4.5% compared to non-users.

Pillbox use was more likely in people with a prior history of good adherence and in women, and became more frequent as the study went on.

Three different statistical methods were used to calculate the impact of pillbox use on adherence, and arrived at an estimate that pillbox use was associated with a 0.34 – 0.37log10 greater reduction in viral load. Pillbox use increased the probability of a viral load below 400 copies/ml by 14.2 - 15.7%.

Multivariable linear regression of the adherence percentage (the difference between current and previous pill counts, divided by the prescribed number of doses for the same period) showed that use of a pillbox organiser had a much greater effect on adherence than once-daily therapy (coefficient of 4.47, compared to 0.78 for once-daily therapy).

In an accompanying editorial Edward Mills of the British Columbia Centre for Excellence in HIV/AIDS and Curtis Cooper of Ottawa Hospital note that “for the occasionally non-adherent patient (e.g. one who takes 90% of the prescribed medications, with a missed dose every 1-2 weeks) the pillbox intervention may have a fundamentally beneficial impact on preventing the development of antiretroviral drug resistance.”

But they warn that for patients with a low level of adherence, “a 5% improvement in adherence may shift a patient from maintaining drug levels that are too low to generate drug resistance to a sub therapeutic plasma antiretroviral level that is insufficient to fully suppress HIV but is high enough to provide sufficient pressure to produce drug resistance.”

Despite this, they conclude that pillboxes are “a simple and effective intervention and should be widely used.”

Sunday, September 9, 2007

New Evidence on How Anti-bodies Fight HIV












How Antibodies Fight HIV: New Evidence
— By furthering scientists' understanding of the molecular mechanisms that separate the minority of successful HIV antibodies from the majority of ineffective antibodies, the work may have implications for future attempts to design an HIV vaccine. The study was published on September 6, 2007,
"This study is part of the effort to understand how protection against HIV occurs," says Dennis Burton, a professor at The Scripps Research Institute. "If we really understand this, then we can design tailor-made vaccines in a way that has never been done before."

Although vaccines have long been used with great success to prevent diseases, scientists are still learning about the exact mechanisms of how vaccines work and how the antibodies that vaccines prompt the body to create can neutralize a pathogen. The spread of HIV, which is resistant to most antibodies the body produces against it, has made fully understanding this method of action more urgent.

With this in mind, Burton and colleagues sought to tease apart the action of the b12 antibody-one of the rare antibodies that protects against the HIV virus. The antibody, first identified by Burton, Scripps Research Professor Carlos Barbas III, and colleagues in 1992, originally came from the bone marrow of a 31-year-old male who had been HIV positive without symptoms for six years.

In the current study, researchers created mutated versions of b12 to see what effect various changes would have on the antibody's effectiveness.

"Hopefully, we can work backwards towards a vaccine, using b12 and the very few other really great, broadly neutralizing antibodies against HIV that have been found," says Scripps Research Senior Research Associate Ann Hessell, who was first author of the Nature paper jointly with Lars Hangartner, a Scripps Research postdoctoral fellow.

Results from the new study suggest the importance of antibody activity against both infected cells and free virus for effective protection. As well as simply binding to HIV, protection was dependent upon the ability of antibodies to interact with immune cell Fc receptors.

Fc receptors are found on the surface of immune cells, such as natural killer cells. The Fc receptor binds to the Fc region of an antibody after an antibody binds to a pathogen, targeting the pathogen for attack by the immune system. Although Fc receptor function was known to be important for the function of antibodies against other diseases, a role in protecting against HIV had never before been demonstrated.

Burton's team examined the ability of two antibodies mutated from b12, dubbed KA and LALA, to prevent infection using the SHIV/macaque model, in which macaques are challenged with a hybrid human-simian virus that infects the model but is recognized by human antibodies. The KA antibody contained a mutation that prevented it from interacting with the complement cascade, a major component of the immune system responsible for destroying invading pathogens. The LALA antibody contained a mutation that rendered it unable to interact with either the complement pathway or the Fc receptor.

In both mutants, the site where the antibody binds to free-floating virus was unaltered, allowing the researchers specifically to investigate the importance of the complement cascade and Fc receptor system for preventing infection.

"We saw that the KA antibody, which could still bind to the Fc receptors on the immune cells but not to the complement cascade, protected the animals from becoming infected just as the wild type b12 antibody," says Hessell. "In contrast, the LALA group became infected much like the controls."

The results provide the first evidence that the Fc receptor, but not the complement cascade, is important to the function of the b12 antibody in preventing HIV infection.

Additional in vitro experiments revealed that the wild type and KA antibodies, but not the LALA antibody, blocked infection more efficiently in the presence of other effector cells of the immune system.

"Our results are fully consistent with the antibody doing two jobs," says Burton, "job one, stick to the virus; job two, recruit immune cells to come and kill infected cells."

In addition to Burton, Hessell, and Hangartner, authors of the study, "Fc Receptor But Not Complement Binding Is Important in Antibody Protection Against HIV," are Meredith Hunter and Preston A. Marx of Tulane University; Carin E.G. Havenith, Frank J. Beurskens, Joost M. Bakker, and Paul W.H.I. Parren of Genmab (Utrecht, The Netherlands); Gary Landucci and Donald N. Forthal of University of California, Irvine, School of Medicine; and Caroline Lanigan of The Scripps Research Institute.

Wednesday, September 5, 2007

HIV EDUCATION & AWARENESS!!!!!!!~~~~~~~~~~~

This WAR on HIV must be won by education & awareness!ef="http://im.Live.com/Messenger/IM/TakeAction/Waitlist/Tracking.aspx?Source=founding_2&UserGuid=ff443f93-f7e7-4f93-8d26-31ebe1841678&Mode=ClickThrough">----IF YOU WOULD LIKE SOMEONE TO TALK OR GIVE A PRESENTATION ON HIV-AIDS CALL ACCESS AIDS SUDBURY 688-0500 OR GO TO 111 ELM ST SUITE 205 & JUST SAY U NEED A SPEAKER ON HIV-HEP-C,LIVING WITH HIV,HIV 101, OR OTHER SUBJECTS OF INTEREST.PEACE N LOVE NOT WARS N WALLS!!ONE DAY AT A TIME,1 LIFE AT A TIME,1 SCHOOL AT A TIME,=CHANGING PEOPLES VIEWS!!

cool pics!

Tuesday, September 4, 2007

Edwina's Story-18 yr African empowered To do,To Be




This WAR on HIV must be won by education & awareness!
Edwina's Story: Celebrating the Empowerment of woman



Africare (Washington, DC)

SPONSOR WIRE
31 August 2007
Posted to the web 31 August 2007

Washington, D.C.

In the village of Nyanga, in Ntungamo District, Uganda, 18-year-old Edwina gazes out the window of her family’s small house, lost in big thoughts. Edwina, the third of nine children, is determined to become a doctor. Her surname, Atusingwire, is a Banyankore name meaning “she has overcome or succeeded” – Edwina thinks of this not merely as a name, but as a prophecy to be fulfilled.

She points to the trees outside her window and breaks her silence. “All these banana plants used to be ours,” she says. Edwina’s soft-spoken voice conveys a warm spirit and sharp intellect. Her large eyes, yellowed from a lingering case of malaria, tell a story of their own.

At 15, Edwina was an excellent student, but her family had no money left to pay for her education. Her parents sold almost everything – house furnishings, cows, land, and most of their banana farm – with the hope of getting at least one of their children through secondary school. Their resources became depleted, yet the family still banked its hopes on Edwina, perhaps due to her sheer determination to succeed. Her dad took up a job as a night watchman at Rwentobo High School, where Edwina was schooling. But his salary was insufficient to keep her in school, let alone meet the basic family needs.

“We had almost nothing left,” recalled Edwina. She wouldn’t let her parents sell their last piece of farmland, an act that would have left her siblings without any means of sustenance.

The Headmaster of Rwentobo High School, Justus Gumisiriza, realized the desperate situation in Edwina’s household. “There was no future left for her,” he said.

Edwina’s case was reported to Africare as preparations were being made to conduct interviews for Africare’s Orphan and Needy Child Scholarship Program in the district. Edwina was included among the candidates, and she later emerged among the 70 successful recipients of the program’s educational scholarships.

Today, after three years on this program, Edwina is an illustrious graduate of Rwentobo High. She is now a first year student studying environmental health at Makerere University. She is the pride of her family.

“Africare is a parent to me,” says Edwina. “They took me up and made me a success.”

The Africare educational support activity in Ntungamo was started in 2001 by the founder and former President of Africare, Mr. C. Payne Lucas, after his visit to the district. Since then, Africare/Washington has continued to raise funds from private sponsors to pay for educational materials and school fees for disadvantaged children like Edwina at Rwentobo High.

“We are indeed very grateful to Africare for helping our school support these orphans and poor children,” said Headmaster Gumisiriza.

This activity has been a seed project from which larger and more comprehensive support has been provided for Orphans and Vulnerable Children (OVC) in Uganda. Africare now provides clean water sources, nutritional support, scholastic grants, peer education and psycho-social support in HIV/AIDS, vocational skills training (to out-of-school OVC), and income generation opportunities to caregivers, as well as organizational capacity strengthening to local governments, NGO partners, and community coordination structures in OVC service delivery.

“It has been well established that economic empowerment of women and their free participation in economic activity are essential to achieving sustainable growth in Africa,” noted Africare Senior Vice President Jeannine B. Scott. “Improvements in the key areas of education and training, agricultural productivity, health and nutrition, and access to water and sanitation are necessary to bring about these changes.”

On Thursday, October 18, 2007, Africare will celebrate the stories like Edwina’s and the empowerment of women in Africa at the seventeenth annual Bishop John T. Walker Memorial Dinner, the largest annual event for Africa in the United States. The Africare Dinner was first held in October 1990 in memory of the late John T. Walker, the first African-American Episcopal bishop of Washington and the longtime chairman of Africare's Board, who passed away on September 30, 1989.

This year’s theme of “women’s empowerment Africa-wide” will be exemplified by a salute to President Ellen Johnson-Sirleaf of Liberia, Africa’s first elected female head of state. At the event, the Africare Board of Directors will present President Johnson-Sirleaf with the 2007 Bishop John T. Walker Distinguished Humanitarian Service Award. Given each year at the Bishop Walker Dinner, the award recognizes those whose work has made a significant impact on raising the standard of living in Africa.

Prior recipients include former Presidents Nelson Mandela, Bill Clinton and Jimmy Carter, and other distinguished persons such as Andrew Young, Dorothy I. Height, Graca Machel, former Secretary of State Colin Powell, and philanthropists Bill and Melinda Gates.

Proceeds from the event help support Africare's mission of assistance to the people of Africa in the areas of food security and agriculture, health and HIV/AIDS, water resource development, environmental management, literacy and vocational training, microenterprise development, governance, and emergency humanitarian aid. The Africare Dinner is a top multicultural affair as well, embracing all races and a wide array of cultures and nationalities from around the world.

SIDE EFFECTS,GLOBAL WARMING vs GLOBAL DIMMING






This WAR on HIV must be won by education & awareness!Entry for September 04, 2007/Living With HIV Isn't All Bad,
Entry for September 04, 2007/Living With HIV Isn't All Bad, magnify
If you can get passed the side effects from meds,well,you have it made!As i have been on meds before but had to stop as i was just sick & tired of being sick & tired...U C ...i am on methadone & haart meds metabilize the methadone 50% faster,& the result was me going into withdrawels over a 2 month period.I would like to see the guy that can handle 2 days of DT's never mind 2 months!!& so now i am seeing the HIV specialist for the first time,& i know i will be starting something,either pega-interferone,or HAART meds,both of which are going to make joe a very sick lad fer abit...frankly i am terrified of going through that experience again,it was that bad folks!!I shit U NoT!!I have gone through many different types of suffering & pain,& this one ranks right up at the top!I am finally stable,& have my life almost back in order(dec 6 trial)except for that,& never mind i wont bother getting into that here.untill its overwith anyways.K so group tomorrow,maybe if its nice enough we can go to the beach,or we can watch a movie.but i want to do something more productive with the group,not sure but i will bring it up for discussion tomorrow.Well NOVA is on & its about GLOBAL DIMMING!!!Now whats this??Altering the worlds rainfall,global dimming has resulted in changes in rainfall,with disasterous effects.Polluted clouds kept the heat of the sun from getting through,thus the life giving rainbelt never moved northwards due to air pollution.50 million peoples R effected directly & alot of suffering will be the obvious result.We must stop useing gas powered cars & trucks & switch to hydrogen as the pollution from that is pure water,thats what we need more of eh folks!!!!Lets PUSH HYDRYGEN FOLKS!!!wanna buy some hydro man??lloljk!so global warming has been slowed by global dimming!!which force will win out in the end??Well,we really need to switch types of cars we drive,i wish i did drive i would try hydro -powered.if i could afford it that is.wow,if the artic ice sheet melts,it could release carbons frozen on the bottem,billions of tons of tonnes!!!GOD help us all eh folks!Well i am happy today anyways,& am not going to let this destroy my good mood i am in.& I hope it gets better for all peoples everywheres!Peace n love not wars n walls eh folks!!